Mpox

Mr.Arroz

Staff member
he/him/his
Hey y'all in NYC: Monkeypox appointments are glitching/reporting as "not available" online, BUT they're still available if you call 877-VAX-4NYC (877-829-4692). I couldn't book online after the appt they tried to give me in Queens (GOD NO) online disappeared, but then I called and it worked out. I'm booked for Sunday in the Bronx. They're still operating under the "are you MSM and had multiple partners in 14 days" stipulations to disqualify people, but I got through. Just passing along.
 

Mr.Arroz

Staff member
he/him/his
One, named ACAM2000, is a modern version of the age-old smallpox vaccine, made from unmodified vaccinia virus, that helped eradicate that disease from humans, a feat WHO celebrated as complete in 1980. FDA approved ACAM2000 in 2007, and the United States has enough of it in its Strategic National Stockpile (SNS) to vaccinate the country’s entire population if there is a bioterror attack with smallpox. Some of the vaccine has been used “off label” for monkeypox in the current outbreak. But vaccinia copies itself after vaccination, which can lead to serious disease, especially in people who have compromised immune systems from HIV—which has a high prevalence among MSM—or other factors.

MVA, the virus in Bavarian Nordic’s vaccine, does not replicate in the body and is much safer, which makes it the preferred vaccine for the monkeypox outbreak. Known as Jynneos in the United States, Imvanex in Europe, and Imvamune in Canada, MVA is the only vaccine FDA has explicitly approved for monkeypox. Because monkeypox is so rare, the company had no human efficacy data when it applied for approval from FDA; the agency granted its license in 2019 in part based on studies showing the vaccine protected animals from monkeypox...

In a study published in The New England Journal of Medicine in 2019, Chaplin and colleagues compared immune responses in people given either MVA or ACAM2000. With smallpox virus, levels of neutralizing antibodies are seen as a key indicator of protection, so the same idea extends to monkeypox virus. The researchers found that 14 days after a single dose, the levels of antibodies that neutralize the monkeypox peaked with MVA, at a level nearly identical to that triggered by ACAM2000. Given that the vaccines are presumed to work postexposure if given within 2 weeks of contact, this suggests that a single dose of MVA could prevent many cases of disease and slow spread.

In a 2008 monkey study led by Moss, published in the Proceedings of the National Academy of Sciences, researchers compared preexposure vaccination against monkeypox from a single dose of MVA and one dose of a cruder version of ACAM2000 called Dryvax. Because MVA does not make copies of itself, the team gave it at a higher dose—similar to what’s used in the Bavarian Nordic shot today—than the Dryvax vaccine.

Both vaccines worked well, but MVA appeared to work faster. Levels of neutralizing antibodies and CD8 cells—critical immune actors that destroy infected cells—both rose more rapidly with MVA, which Moss and coworkers concluded was because it took time for Dryvax to replicate to levels that matched the initial shot of MVA. What’s more, when they injected the animals with the monkeypox virus just 4 days after vaccination, it grew less well in monkeys vaccinated with MVA.

In a statement to Science, CDC stressed that a single dose of the vaccine hasn’t been studied in any outbreak and cautioned that it is “challenging” to extrapolate from immune responses in earlier studies and protection in animal studies.

https://www.science.org/content/art...ox-vaccine-could-one-dose-instead-two-suffice

JYNNEOS is the version that NYC is distributing (contains MVA).
 
Didn’t see a thread for it. Here comes the next pandemic already. The gay community, at this point, is being heavily affected. Have you gotten vaccinated yet?





 
I've been waiting for a monkeypox thread. Obviously it is heavily impacting the queer community in particular, but it did feel weird to be talking about it in the LGBTQIA+ thread while also fighting the stigmatization of it being viewed as a "gay" thing.
 
this whole situation sucks - it's great to see public health depts. reaching out to the gay community and prioritizing them in administering the scarce supply of vaccines. but at the same time, it's super uncomfortable that the virus is being associated with the LGBTQ+ community; it plays into a bunch of harmful tropes. It really couldn't have happened at a worse time in the US with the rising anti-gay sentiment.
 
Got vaccinated last night. I’m grateful my city is prioritizing MSM who are at a high risk, but not thrilled that it’s also feeding a notion that it’s a gay disease.

And yes, echo sentiments that the media has done a mostly terrible job of clarifying that this is not an STI.
 
The eligibility of the vaccine in the US thus far is completely wild, and heavily stigmatizing. Wait times have also been insane, and because I don't think I'm at high-risk I'll wait for things to get better.

Also, I keep seeing reports that the smallpox vaccine can fight infection, so could they potentially prioritize using that vaccine as well?
 
The eligibility of the vaccine in the US thus far is completely wild, and heavily stigmatizing. Wait times have also been insane, and because I don't think I'm at high-risk I'll wait for things to get better.

Also, I keep seeing reports that the smallpox vaccine can fight infection, so could they potentially prioritize using that vaccine as well?
The problem with that vaccine is it has more side effects, so I think they’re avoiding using it unless they have to.
 
I ran to get my vaccine in the second wave of releases (before lots of folks in NYC viewed Monkeypox as a 'threat') just under 3 weeks ago--I'm slightly concerned that larger cities have taken the '1 shot for everyone approach' so my second shot likely won't be for at least another month and one-shot efficacy hasn't been extensively studied in humans, but it's also better than nothing, and understand getting folks a baseline level of immunity is important too.
 
(just realized that in consolidating all monkeypox posts from amongst LGBTQIA+ and other threads it makes it look like I created this thread and KIIIIIII)

this is still all you @beautifulmorning
As long as it gets the word out, no biggie. I know a lot of people are trying to find out where to get vaccinated and what the process is like, not to mention trying to find out what one can expect if one does get monkey pox.
 
I got Jynneos 1/2 last week and at the time, residents of New Jersey were being told to just try their luck “in New York” (the situation has since improved; there are vaccination sites in Jersey City and Newark now). I had to go to freaking White Plains! I know I benefited from this so I am a hypocrite, but it is upsetting how poorly the vaccine rollout has gone and how it seems like the only folks within the queer community consistently able to get vaccinated are the tech-enabled PMC types.
 
While I understand that you can’t just snap your fingers and instantly produce millions of vaccines, is it wrong to slightly side-eye the announcement that the USA is ordering another 5.5 million doses for … the middle of 2023? Tick tock!!
 
They do not care about us. Until this affects a larger portion of the straight-white population, nothing drastic will be done.

My mom is a huge ally so I know she didn’t mean this with an ounce of malice, but she asked me tonight if I should be getting the vaccine, as if Heather doesn’t know she’s the only person I hang out with!
 
While I understand that you can’t just snap your fingers and instantly produce millions of vaccines, is it wrong to slightly side-eye the announcement that the USA is ordering another 5.5 million doses for … the middle of 2023? Tick tock!!

Don’t they mean now “through” 2023?

“The U.S. has shipped more than 300,000 doses of the Jynneos vaccine to state and local health authorities since May, according to the Biden administration. HHS also has secured an additional 5 million doses for the U.S. that will ship through the middle of 2023.”
 
Don’t they mean now “through” 2023?

“The U.S. has shipped more than 300,000 doses of the Jynneos vaccine to state and local health authorities since May, according to the Biden administration. HHS also has secured an additional 5 million doses for the U.S. that will ship through the middle of 2023.”
The only reference I found to the contrary on first skim was in USA Today, that the “supplies are in manufacturer storage, which will be ready in 2023.”
 
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